Region-Restricted Antigen Presentation to T Antigen-Processing Event Required for I- Pillars Article: Identification of a Macrophage
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Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.
The mechanism of macrophage-antigen handling was studied using a system that involves the quantitation of the antigen-specific binding of Listeria monocytogenes-immune T cells to macrophages. Specific T cells did not bind to native antigen. Because the specific binding of T cells to macrophages could be measured during a short (5- to 15-min) interaction, it was possible to follow the temporal d...
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The macrophage first gained recognition in the early 192O's and 193O's as the cell responsible for clearing antigen and synthesizing antibody (Sabin 1923). Its importance to the immune response faded with the realization that lymphocytes and not macrophages were the origin of antibody molecules and it was not until the early 196O's that experiments suggested that antigen processing by the macro...
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The Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) is expressed in all EBV-associated tumors, making it an important target for immunotherapy. However, evidence for major histocompatibility complex (MHC) class I-restricted EBNA1 peptides endogenously presented by EBV-transformed B and tumor cells remains elusive. Here we describe for the first time the identification of an endogenou...
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